Mister Negative in Spider-Man 2.
Screenshot by Destructoid.

All Villains in Marvel’s Spider-Man 2

A city of bad guys.

In Spider-Man 2, New York is teeming with enemies. You’ll exchange blows with them, but this time around the bad guys also have to worry about Kraven who is on the hunt for the best prey. Keep an eye out for all the villains that make cameos in Spider-Man 2.

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Black Cat in Spider-Man 2.
Screenshot by Destructoid.

Black Cat – Felicia Hardy

Black Cat makes a return, though her intentions aren’t too devious this time around. Encounters with her are exhilarating, and Insomniac shows some of what it learned from Ratchet & Clank: Rift Apart‘s development.

Grizzly in Spider-Man 2.
Screenshot by Destructoid.

Grizzly – Maxwell Markham

Grizzly is a minor villain that spoils Peter Parker’s night as he tries to spend time with MJ and Harry. He’s a wrestler turned bad guy, and you’ll find him wearing a bearskin cape.

Kraven the Hunter in Spider-Man 2.
Screenshot by Destructoid.

Kraven the Hunter – Sergei Kravinoff

Kraven is one of the primary foes in Spider-Man 2. He’s a burly man who has a tiger as a pet and countless goons working for him. He sees all heroes and villains as game that he must hunt to prove his superiority. When he sets his eyes on New York, it spells trouble for the Spider-Men.

Lizard in Spider-Man 2.
Screenshot by Destructoid.

Lizard – Curtis Connors

Curtis Connors is Harry’s doctor, and for the most part, he isn’t actually a villain, at least not until he transforms into the Lizard. In this reptilian form, he becomes a destructive monster that is nearly impossible to reign in. Your battle against him is a fun one that has you web-swinging through the city as you try to catch up to the rubble-making reptile.

Martin Lee in Spider-Man 2.
Screenshot by Destructoid.

Mister Negative – Martin Lee

Mister Negative and Miles Morales have some history, which makes a showdown between the two inevitable. The battle with Mister Negative will test your combat skills, but it also provides an interesting look into Mile’s psyche.

Miles Morales in Spider-Man 2.
Screenshot by Destructoid.

Mysterio – Quentin Beck

Mysterio is a master of illusions and his missions are some of the most fun in the game, as they’re set in a neon virtual world. He’s set up various Mysterio challenges around the city. They’re great to hone your combat skills, and you can keep doing them to improve your previous performance times.

Sandman in Spider-Man 2.
Screenshot by Destructoid.

Sandman – Flint Marko

Sandman is the first villain you face off against. It’s an extremely cinematic experience that sets up the rest of the action-packed adventure quite well. He isn’t entirely villainous, and through collectibles, you can discover what causes him to lash out.

Scorpion in Spider-Man 2.
Screenshot by Destructoid.

Scorpion – Mac Gargan

Scorpion is a minor villain that receives minimal screen time. You won’t have to worry about him too much, as Kraven takes care of him.

Spider-Man 2 Venom
Screenshot via Insomniac Games.

Symbiote/Venom/Scream

Alongside Kraven, Venom is one of the main foes of Spider-Man 2. The symbiote is an alien parasite that clings to a host. At first, the host feels more powerful, but the symbiote gradually takes control of them until they become the villainous Venom. When a symbiote takes control of MJ, Scream is formed.

Yuri in Spider-Man 2.
Screenshot by Destructoid.

Wraith – Yuri Watanabe

There’s an arsonist cult lighting fires in New York. As you stop them, you’ll cross paths with Yuri who also wants to eliminate the cult. The only problem is that Spider-Man and Yuri have different ideas of what justice is, leading to a showdown. She’s not truly a villain, though she has a bloodthirsty approach to crime-fighting.

To avoid being overpowered by your foes, remember to upgrade your Suit Tech and Gadgets. This will equip you with more moves and abilities.


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Author
Image of Smangaliso Simelane
Smangaliso Simelane
Staff Writer - Smangaliso Simelane is a writer with a passion for all things related to video games. He has been writing about video games since 2020.